SAMe is formed naturally in the body from homocysteine and 5-methylene tetrahydrofolate (1). It serves as a methyl group donor for many processes in the body such as synthesis, activation, and metabolism of hormones, neurotransmitters, nucleic acids, proteins, and phospholipids (2,3,4). SAMe has revealed benefits in osteoarthritis for reducing pain when compared to NSAIDs such as celebrex (5,6,7). As a precursor to serotonin, a neurotransmitter involved in depression, several clinical studies have noted improved outcomes when used in those with depression and is actually used as a prescription in some areas of Europe (8,9).
Do not use SAMe and prescription antidepressants together. SAMe should be taken as recommended by a healthcare professional to assess if appropriate for you.