PEA (Palmitoylethanolamide), an endogenous (manufactured by the body) fatty acid amide, helps to relieve chronic pain and inflammation. As an endogenous agent and one also found in foods such as eggs and milk, no serious side effects or drug–drug interactions been identified.
PEA has demonstrated effectiveness for chronic pain of multiple types associated with many painful conditions, especially with neuropathic (nerve) pain, inflammatory pain and visceral pain such as endometriosis and interstitial cystitis.
Two particularly interesting processes have been proposed as to how PEA improves pain. First, PEA is not analgesic strictly speaking since it does not modify the physiological pain threshold per se, rather it normalizes conditions of hypersensitivity within the peripheral and central nervous system that arise from neuroinflammatiom. Second, PEA not only relieves pain itself but it also improves pain-induced cognitive impairments through its actions in the brain.
PEA should be taken as recommended by a Health Care Professional.