Glucosamine Sulfate is a stable, clinically studied source of glucosamine, which is the fundamental building block required for the synthesis of connective tissue subunits (glycosaminoglycans). Glucosamine is an essential building block of proteoglycans, hyaluronic acid (a component of joint lubrication) and glycolipids, and it is essential for the proper formation of tendons, ligaments, synovial fluid, bones, skin, nails, and blood vessels(1)(2)(3)(4)(5)(6)(7)(8)(9). Joint builder glucosamine is naturally water-soluble, and low in molecular weight, thereby offering rapid and high absorption (over 90%).

MSM (Methyl-sulfonyl methane) is a sulfur donor, which is essential to the formation of the chondroitin sulfates. Sulfur is essential for numerous electrochemical, catalytic and structural functions in human metabolism. Sulfur is a key component of MSM, which helps connective tissues and joints, and is needed for enzyme activity, hormone balance, and function of the immune system. As a central component of collagen and connective tissue, sulfur assists the body in preventing inflammation and facilitating repair of connective tissues(10)(11).

Devils Claw, a tuber from Africa, is primarily known for use in arthritis. It reduces inflammation and is analgesic in joints and connective tissue. Clinical studies have shown that it is effective in alleviating arthritic symptoms(14). The harpagosides in Devils Claw are mostly responsible for this(15). It can be used for long term or new joint pain. It can also alleviate pain from overuse as well.

Recent research has implicated nutritional factors as important in the maintenance of bone and joint health. Despite the increasing recognition that osteoarthritis and osteoporosis may have nutritional abnormalities at the root of their causation, dietary programs have often played a secondary role in the management of these diseases. Recently, nutritional interventions(16), and supplementation have been increasingly proposed as effective options for these disorders, which are often unresponsive to current, conventional medical interventions.